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In addition, there was no increase in antipsychotic-related side effects, and compliance was enhanced.

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The nonspecific effects of being in a treatment trial may be greater in patients with chronic, refractory forms of schizophrenia than in those who are either having acute exacerbations or are in earlier phases of the illness.

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The results highlight that a standardised approach to improved pain management is a practical intervention that would be straightforward to implement widely for the benefit of agitation in residents of nursing homes with dementia.

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BPRS total score, BPRS psychosis cluster, and CGI severity score; the 3 highest risperidone dose groups were generally superior to placebo on the PANSS negative subscale.

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The prescriber should be aware that these figures cannot be used to predict the incidence of side effects in the course of usual medical practice where patient characteristics and other factors differ from those which prevailed in this clinical trial.

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In the second study of chronic hospitalized patients with schizophrenia followed up for one year, of 40 patients treated with long-acting risperidone, 83% were discharged and none readmitted.

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Since non-compliant patients, although representing a significant proportion of real-world patients with schizophrenia and other psychoses, are rarely recruited to clinical trials, this poses problems in demonstrating the benefit of a treatment that is likely to be advantageous in that very population.

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Based on the magnitude of improvement in randomised controlled trials of non-drug interventions for agitation in residents of nursing homes, we estimated that a 25% greater reduction of Cohen-Mansfield agitation inventory score in the intervention group compared with control group would indicate equivalence to the best currently available approaches.

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